Parkinson's and the Gut; Medication Absorption

Understanding Parkinson's Disease Medication Absorption

Oral levodopa tablets are one of the most commonly prescribed medications for Parkinson's disease. These tablets work by being absorbed in the small intestine—not the stomach—before traveling through the bloodstream to the brain, where levodopa acts as a dopamine replacement therapy.

What Can Affect Absorption?

·      Slowed digestive transit

·      Constipation

·      Less commonly, protein-rich meals

Slowed transit and constipation can delay levodopa reaching the small intestine and impact the efficacy.

The Protein Factor

You may come across information about the impact of protein. This is because the digestive tract contains receptors that break down dietary proteins and transfer them into the bloodstream. Very occasionally, the body may prioritise absorbing these food components first, potentially only partially absorbing medications.

Does this matter?

Medication absorption varies from person to person. Most people will not have difficulties. It is important not to cut out any nutrient or protein rich foods unless deemed entirely necessary by your medical team.

Stay tuned for part 4 of PD and the gut - Weight loss